P-764 Mode of conception and future neurologic morbidity of the offspring: a sibling analysis

Abstract Study question To investigate the risk of long-term neurological morbidity among children born following fertility treatments while employing sibling matched analysis to maximize confounder control. Summary answer Fertility appear be an independent factor for offspring up 18 years age. What is known already Controversy exists regarding association between and offspring. design, size, duration A retrospective population-based cohort was performed, including all deliveries occurring 1991 2021 at a tertiary medical center. Offspring were followed-up until age years. Participants/materials, setting, methods The study population included 10,810 siblings women who had least one spontaneous pregnancy - in vitro fertilization (IVF) ovulation induction (OI). Kaplan–Meier survival curve used compare cumulative neurologic incidence multivariable Cox hazards regression model control confounders. Main results role chance There 5,935 (54.9%) conceived treatment 4875 spontaneously (45.1%). Gestational diabetes mellitus hypertensive disorders more common group (9.9% vs. 5%, 7.7% 4.7%, respectively, p < 0.001). Likewise, rates Cesarean delivery (33.6% 2.3%, 0.001), preterm (11.9% vs 7.6%, 0.001) low birth weight (12.1% vs.7.2%, higher group, as compared with group. Neurological significantly those (10.2% 8.2%; In particular, psychiatric emotional (4.4% 3.3% = 0.002). Using Kaplan-Meier curve, (Log-Rank, 0.012). After controlling confounders, such maternal age, mellitus, disorders, using model, being associated long term (adjusted HR 1.2, 95% CI 1.02-1.32, 0.027). Limitations, reasons caution This can only provide evidence but not causation. Also, our are hospital-based diagnoses which most likely represent acute severe disease. Wider implications findings this large siblings, significant found morbidities. Trial registration number N/A